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Properties and amenities used in the manufacture of intermediates and APIs ought to be Situated, made, and constructed to facilitate cleaning, upkeep, and operations as appropriate to the sort and phase of manufacture.Intermediates held for even further processing should be stored below correct conditions to make sure their suitability to be used.A

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The distribution design and style should really contain The location of sampling valves while in the storage tank and at other places, including inside the return line of the recirculating water program. Wherever possible, the main sampling sites for water should be the valves that provide water into the points of use. Immediate connections to proc

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